As they worked on creating synths, they attempted to work peacefully with the people of the Commonwealth using first generation synths, but mutual mistrust ended that relationship quickly and they returned to isolation. Isolated from the outside world, the scientists continued their work, disregarding the mayhem and destruction occurring outside of its grounds. The Institute was formally founded in 2110, as the children of the original survivors dug into the earth and built increasingly sophisticated habitats and laboratories, starting an ongoing process of expanding the Institute's facilities and infrastructure. While the college itself was completely destroyed in the flames of the Great War in 2077, the science staff took refuge in the underground of the Institute and carved out a subterranean habitat for themselves. The Institute formed out of the ashes of what was once known as the Commonwealth Institute of Technology (CIT). 6 Interactions with the player character.